For patients and physicians who have questions about statins, the American Heart Association has the following information.

“Statins are among our best drugs for treating individuals who have elevated cholesterol,” said Alice K. Jacobs, M.D., past president of the American Heart Association.  “The public should know that these drugs are safe.  Overwhelmingly, the majority of individuals tolerate statins very well, and the absolute risk of side effects is low.”

For patients, the American Heart Association recommends:

• Statins are one of the most effective drugs to reduce elevated low-density lipoprotein (LDL) or “bad” cholesterol, which is associated with increased risk of cardiovascular disease.
• The absolute risk of side effects from statins -- including rosuvastatin (Crestor), atorvastatin (Lipitor), simvastatin (Zocor), and pravastatin (Pravachol) -- is low.
• Patients who are currently taking a statin should continue to take their medication as prescribed and consult with their physician if they have any question about dosage or risk of side effects.
• No medication should be discontinued without consulting a physician. Be aware of potential side effects and risks that can develop while taking the drug or after stopping the drug, and discuss them with a physician. 
• Report side effects to your doctor when they occur; do not wait for the next visit. 
• Higher doses of statins may be associated with a greater risk of side effects.  Side effects tend to be dose-related and may disappear after reducing the dosage or, if necessary, withdrawing the medication.
• The only time patients should stop taking their statins is if they experience muscle pain or dark urine, and they should notify their physician immediately. 

For physicians and other health care providers, the American Heart Association recommends:

• The dose of statins should not exceed the level required to achieve current goals of therapy.
• Be knowledgeable of the factors that may increase the risk of myopathy (muscle weakness).  For a complete list, see related link on The Issue of Statin Safety:  Where Do We Stand
• Consider using combinations of cholesterol-lowering drugs at lower doses for patients at increased risk for myopathy.
• Report adverse events to the FDA, to optimize the post-marketing surveillance system.
• Select statins based on the degree of LDL-lowering required to achieve the patient’s recommended goal, the potential for side effects, and the patient’s preferences (e.g., compliance, costs, etc.).
• The risks of specific statins should be weighed for each patient.  In general, physicians should prescribe the lowest dose of statin to bring a patient’s cholesterol to target levels.