Science News from the 62nd High Blood Pressure Research Conference 2008

Omni Hotel at CNN Center - Atlanta, Ga.
Sept. 17-20, 2008

Welcome Message | Saturday Presentations | Friday PresentationsThursday Presentations | Wednesday Presentations | News Release | Top 12 List

R. Clinton Webb
On behalf of the American Heart Association Council for High Blood Pressure Research, in association with the Council on the Kidney in Cardiovascular Disease, we welcome you to the 62nd High Blood Pressure Research (HBPR) Conference, Sept.17-20, 2008, at the Omni Hotel at CNN Center, Atlanta, Ga.

The conference is considered one of the most important medical meetings on recent advances in hypertension research in the world. It routinely draws an international audience of over 650 attendees. The program includes state-of-the-art lectures and oral and poster presentations selected from abstracts submitted by clinical and basic researchers from 20 countries, all followed by discussions led by authorities. The conference will provide an educational program for physicians and research investigators that will enhance their knowledge, advance their skills, and apprise them of the latest developments in research pertaining to hypertension, stroke, kidney function, obesity and genetics.

We sincerely hope that you can join us this week in Atlanta for the 62nd HBPR Conference. For the latest conference information, visit My.AmericanHeart.org for Professionals.

Sincerely,

signature


R. Clinton Webb, Program Chair
Council for High Blood Pressure Research Annual Conference

 

 



Highlighted Presentations – Saturday

Renin Progenitor Cells Contribute to Juxtaglomerular Cell Hyperplasia in Adult Mice
Hao Wang, Duke University Medical Center, Durham, N.C.
Presentation Slides

Endothelin-1 (et-1) Contributes To Erectile Dysfunction In Doca-salt Hypertensive Rats
Fernando S. Carneiro, Medical College of Georgia, Augusta, Ga.
Presentation Slides

G-protein Coupled Receptor Kinase-2 (GRK-2)-mediated Regulation of Blood Pressure In SHR and the Role of PPPARg
Mohammad Newaz, Texas Southern University, Houston, Texas
Presentation Slides

Interaction Between P450 Eicosanoids And Nitric Oxide In The Control Of Arterial Tone In Mice: Implications For Soluble Epoxide Hydrolase Inhibition In Hypertension
Hantz C. Hercule, Franz Volhard Clinic and Nephrology/Intensive Care, Berlin, Germany
Presentation Slides

Renal Medullary 11β-Hydroxysteroid Dehydrogenase Type 1 in Dahl salt-sensitive hypertension
Yong Liu,  Medical College of Wisconsin, Milwaukee, Wis.
Presentation Slides

Klotho Gene Delivery Prevented Progression of Spontaneous Hypertension
Yuhong Wang, Zhongjie Sun, University of Oklahoma, Oklahoma City, Okla.
Presentation Slides




Highlighted Presentations – Friday

Role of Dopamine D2 receptors in the regulation of renal inflammation
Ines Armando, Georgetown University Medical Center, Washington, D.C.
Presentation Slides

Decreased Activation of Postsynaptic Alpha2-Adrenoceptors Contributes to the Chronic Blood Pressure Lowering Effects of the Carotid Baroreflex During Adrenergic Blockade
Thomas E. Lohmeier, CVRx, Inc., Maple Grove, Minn.
Presentation Slides

Renin-Independent Processing of Angiotensin-(1-12) in the Rat Heart
Aaron J. Trask, Wake Forest University School of Medicine, Winston-Salem, N.C.
Presentation Slides

Monocyte Chemoattractant Protein-1 Mediates Myocardial Microvascular Dysfunction in Swine Renovascular Hypertension
Lilach O. Lerman , Mayo Clinic, Rochester, Minn.
Presentation Slides

Critical Role of Angiotensin Converting Enzyme Level in Myocardial Ischemia-Reperfusion Injury Revealed by Gene Titration in the Mouse
Erij Messadi-Laribi, Inserm U872, CRC, Paris, France
Presentation Slides

Translational Research Goes Both Ways: Lessons for Basic Biology from Clinical Studies
Dr. John W. Funder, M.D., Ph.D., FAHA, Prince Henry’s Institute of Medical Research, Melbourne, Australia
Presentation Slides

Sex Differences in the Aging-Dependent Renal Changes When COX-2 Activity Is Reduced During Renal Development
Fara Sáez, University of Murcia, Murcia, Spain
Presentation Slides

Nitroglycerine and Desmopressin in the Treatment of Supine Hypertension, Nocturnal Polyuria and Morning Orthostatic Tolerance in Autonomic Failure
Luis E. Okamoto, Vanderbilt University, Nashville, Tenn.
Presentation Slides 

Treatment of Obese Diabetic Mice with an Heme Oxygenase Inducer Reduces Visceral and Subcutaneous Adiposity, Increases Adiponectin Levels and Improves Insulin Sensitivity and Glucose Tolerance
Stephen J. Peterson, New York Medical College, Valhalla, NY; Ming Li, Dong Hyun Kim, Pharmacology, New York Medical College, Valhalla, N.Y.
Presentation Slides

Nuclear Angiotensin II AT1 Receptors Mediate the Formation of Reactive Oxygen Species
Karl Pendergrass, Wake Forest University, Winston-Salem, N.C.
Presentation Slides

 

Highlighted Presentations – Thursday
The Donald Seldin Lecture
The “New” Systems Biology and the Renal Action of Vasopressin
Mark A. Knepper, M.D., Ph.D., National Heart, Lung, and Blood Institute, Bethesda, Md.
Presentation Slides
Spotlight on Award Finalists
Imbalance of AT1R and AT2R in the RVLM: Potential Mechanism for Sympathetic Overactivity in Heart Failure
Lie Gao, University of Nebraska Medical Center, Omaha, Neb.
Presentation Slides

Selective Ablation Of AT1a Receptors In Rostral Ventrolateral Medulla (RVLM) Prevents Chronic Angiotensin-II-dependent Hypertension In Part By Reducing Oxidant Stress In This Region
Valdir A. Braga, Cornell University, Ithaca, N.Y.
Presentation Slides

AT1 Receptors On Bone Marrow Cells Modulate Kidney Injury In Hypertension
Steven D. Crowley, Duke University Medical Center, Durham, N.C.
Presentation Slides

Other Presentations
Interleukin-6 Stimulates Epithelial Sodium Channels via Proteolysis in the Mouse Cortical Collecting Duct Cells
Ke Li, Medical College Georgia, Augusta, Ga.
Presentation Slides

Renal Tubular Dysfunction in Hypertensive Rats: Roles of Superoxide and NHERF
Carolina Panico, Georgetown University, Washington, D.C.
Presentation Slides

Central Infusion Of Minocycline Inhibits Proinflammatory Cytokines In The Pvn And Attenuates Ang II - Induced Hypertension
Carlos C. Diez Freire, University of Florida, Gainesville, Fla.
Presentation Slides

Human Angiotensinogen Haplotype Containing -217A Increases Blood Pressure in Transgenic Mice as Compared to the Haplotype Containing -217G
Sudhir Jain, New York Medical College, Valhalla, N.Y.
Presentation Slides

Cerebro-renal Connection: Involvement Of Large Artery Stiffening In Microvascular Organ Damage
Junichiro Hashimoto, Tomoyuki Aikawa, Yutaka Imai, Tohoku University, Sendai, Japan
Presentation Slides

Steroidogenic Factor-1 Inhibits Adrenal Cell Aldosterone Synthase by Blocking Expression of NURR-1
Ping Ye, Medical College of Georgia, Augusta, Ga.
Presentation Slides

Non-genomic vascular signaling by aldosterone involves the novel Mg2+ transporter Transient Receptor Potential Melastatin 7 (TRPM7) cation channel
Alvaro Yogi, Kidney Research Center, Ottawa, Ontario, Canada
Presentation Slides

Hyperaldosteronism is Equally Common in African American and White Patients with Resistant Hypertension
Saima Husain, University of Alabama at Birmingham, Birmingham, Ala.
Presentation Slides

Eplerenone Deceases Aldosterone Salt-induced Cardiac Fibrosis and Reduces Oxidative Stress In Angiotensin II Type 1a Knockout Mice via Rho-kinase Inhibition
Shuntarou Kagiyama, Kiyoshi Matsumura, Mitsuo Iida, Kyushu University, Fukuoka, Japan
Presentation Slides

The Effects Of Darbepoetin On Endothelial Progenitor Cells In Patients With Chronic Kidney Disease
Rosemarie L. Shim, University of Michigan, Ann Arbor, Mich.
Presentation Slides




Highlighted Presentations – Wednesday
Plenary Lecture:
Past, Present and Future of Signaling Pathways in the Vascular Wall
Professor Paul M. Vanhoutte, Ph.D.
Head of Pharmacology, University of Hong Kong
Presentation Slides

Intrarenal AT1R Blockade Or Ang III Infusion Induces AT2R Translocation To The Apical Membrane Of Renal Proximal Tubule Cells In WKY But Not In SHR
Shetal H. Padia, University of Virginia Health System, Charlottesville, Va.
View Poster

A Randomized Trial of Music Versus Audio Guided-relaxation Training to Decrease Blood Rressure in an Elderly Population
Hsin-Yi Tang, Verna Harms, Seattle University, Seattle, Wash.; Sarah M. Speck, Swedish Medical Center, Seattle, Wash.; Toni Vezeau, Seattle University, Seattle, Wash.
View Poster



News Release
Audio relaxation program may help lower blood pressure in elderly
Study highlights an audio-guided relaxation CD with background sounds of ocean waves and a calming voice may lower blood pressure in elderly people.

Listening to Mozart also significantly lowered blood pressure in the study, but to a lesser degree.

The technique has been used for chronic pain, but had never been tested in the hypertensive elderly.



The Top 12 Things You are Missing if You Are Not Attending the High Blood Pressure Research Annual Conference 2008

1. State of the art presentations

The Pump, the Exchanger and the Holy Spirit: How Salt Causes Hypertension
Dr. Mordecai P. Blaustein, M.D., FAHA
Professor of Physiology and Medicine, University of Maryland, Baltimore

Translational Research Goes Both Ways: Lessons for Basic Biology from Clinical Studies
Dr. John W. Funder, M.D., Ph.D., FAHA
Senior Fellow, Prince Henry’s Institute of Medical Research, Prince Henry's Institute of Medical Research

The Role of X-Ray and MRI Imaging in Assessing Renal Function in Health and Disease
Dr. Juan Carlos Romero, M.D., FAHA
Professor of Physiology and Medicine; Director, Hypertension Research Laboratories, Mayo Clinic College of Medicine

2. Distinguished Achievement Awards

High Blood Pressure Research Council
Robert M. Carey, M.D., FAHA
David A. Harrison III Distinguished Professor of Medicine, University of Virginia 

Council on Kidney in Cardiovascular Disease
L. Lee Hamm, M.D., FACP, FAHA
Huberwald Professor & Chair of Medicine
Executive Vice Dean, Tulane University School of Medicine

3. The Donald Seldin Lecture
The “New” Systems Biology and the Action of Vasopressin in the Kidney
Dr. Mark A. Knepper, M.D., Ph.D., FAHA
Senior Investigator and Chief, Laboratory of Kidney and Electrolyte Metabolism National Heart, Lung, and Blood Institute, Bethesda, Md.

4. Networking opportunities with established investigators in HBPR research.

5. High Blood Pressure and Kidney Council New Investigator Awards.

6. Harry Goldblatt New Investigator Awards  

AT1 Receptors On Bone Marrow Cells Modulate Kidney Injury In Hypertension
Steven D. Crowley, M.D., Duke University Medical Center, Durham, N.C.

Urinary Angiotensinogen as a Novel Biomarker of the Intrarenal Status of the Renin-Angiotensin System in Hypertensive Patients
Hiroyuki Kobori, M.D., Ph.D., Tulane University, New Orleans, La.

Novel Role for Hypothalamic Mammalian Target of Rapamycin (mTOR) in Sympathetic and Circulatory Control
Kamal Rahmouni, Ph.D., Univeristy of Iowa, Iowa City, Iowa

7. Irvine Page – Alva Bradley Lifetime Achievement Award
K. Bridget Brosnihan, Ph.D., FAHA
Professor and Co-Director of Molecular Medicine Program, Wake Forest University, Winston-Salem, N.C.

8. Lewis K Dahl Memorial Lecture
Mysteries of Renal Autoregulatory Control
Edward W. Inscho, Ph.D., FAHA, Professor and Program Director, M.D./Ph.D. Program, Medical College of Georgia, August, Ga.

9. Harriet Dustan Award. Saturday
Estrogen and the Female Arteries: The Secret to a Long Life
Suzanne Oparil, M.D., FAHA, Director, Vascular Biology and Hypertension Program; Professor of Medicine and Physiology & Biophysics, University of Alabama, Birmingham

10. Arthur C Corcoran Memorial Lecture
Sympathetic Activity, Vascular Capacitance and Long-term Regulation of Arterial Pressure
Gregory D. Fink, Ph.D., FAHA, Professor, Michigan State UniversityEast Lansing, Mich.

11. Opening Keynote Presentation by Paul Vanhoutte
Plenary Lecture:
Past, Present and Future of Signaling Pathways in the Vascular Wall
Professor Paul M. Vanhoutte, Ph.D.
Head of Pharmacology, University of Hong Kong

12. Three Poster Sessions

Poster Session I

• Angiotensin Receptors and Signal Transduction

• Central Neural Mechanisms

• Endothelial Interactions

• Novel Therapeutic Approaches to Hypertension

• Peripheral Neural Mechanisms

• Regulation of Renin-Angiotensin System

• Renal Tubular Transport and Natriuretic Factors

• Vascular Biology

• Vascular Signaling

• Late Breaking

Poster Session II

• Aldosterone and Adrenal Mechanisms

• Cardiac Hypertrophy and Dysfunction

• Central Neural Mechanisms

• Predicting Risk in Human Hypertension

• Molecular and Cellular Physiology

• Obesity, Insulin and Metabolic Factors

• Regulation of Renin-Angiotensin System

• Sex Pregnancy and Hypertension

• Vascular Remodeling and Dysfunction

• Late Breaking

Poster Session III

• Clinical and Epidemiological Aspects of Hypertension

• Experimental Genetic Models and New Approaches

• Genetics of Hypertension

• Obesity, Insulin and Metabolic Factors

• Pathogenesis of Hypertension

• Receptors and Signal Transduction

• Renal Hemodynamics and Vascular Function

• Renal Inflammation, Injury and Diabetes

• Vasoactive Mediators and Autacoids

• Late Breaking

 


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