AHA/ASA/ACCF Percutaneous Device Closure of Patent Foramen Ovale for Secondary Stroke Prevention: A Call for Completion of Randomized Clinical Trials

• Observational studies suggest a strong association between patent foramen ovale (PFO) and cryptogenic stroke (CS).
• A causal relationship has not been convincingly established for most affected patients.
• Randomized controlled trials offer the best means to help resolve the uncertainty regarding optimal care for patients with CS and PFO.

Supporting Materials
Top Ten Things to Know | AHA/ASA statements and guidelines related to stroke | Get With The Guidelines–Stroke