Science News from the 63rd High Blood Pressure Research Conference 2009

September 23-26, 2009
InterContinental Chicago O’Hare Hotel Chicago, Ill.

On behalf of the American Heart Association Council for High Blood Pressure Research, in association with the Council on the Kidney in Cardiovascular Disease, we cordially invite you to attend the 63rd High Blood Pressure Research (HBPR) Conference Sept. 23-26, 2009, at the InterContinental Chicago O’Hare Hotel in Chicago, Ill.

This conference, focusing on recent advances in hypertension research, is considered one of the most important medical meetings on this subject in the world. The meeting, preceded by a one-day workshop, includes oral and poster presentations selected from abstracts submitted by clinical and basic researchers and draws an international audience of more than 700 attendees. The conference will provide an educational program for physicians and research investigators that will enhance their knowledge, advance their skills, and apprise them of the latest developments in research pertaining to hypertension and its relationship to stroke, cardiac disease, kidney function/renal diseases, obesity and genetics. We sincerely hope that you will make plans to join us this fall in Chicago for the 63^rd HBPR Conference.

Sincerely,

Rhian M. Touyz, M.D., Ph.D., FAHA
Program Chair, Council for High Blood Pressure Research Conference
Ottawa Health Research Institute, University of Ottawa, Canada

Highlighted Presentations — Wednesday

Keynote Presentation

Genes, Molecules, Systems Biology and Epidemiology — Bringing it All Together Through Framingham
Daniel Levy, M.D., Framingham, Mass.
Presentation Slides

Featured Presentation

Sex Differences in Proximal Tubule-derived Angiotensinogen (AGT), Renin and Prorenin Receptors-(P)RR- in Collecting Ducts May Help To Explain Sexual Dimorphism of Hypertension and Kidney Injury
Vicky F. Rands, Kimberly L. Kavanagh, Victoria L. Martin, Minolfa C. Prieto, Tulane Univ, New Orleans, La.
Presentation Slides

Highlighted Presentations — Thursday

2009 Irvine Page-Alva Bradley Lifetime Achievement Award in Hypertension

Leopoldo Raij, M.D., FAHA
University of Miami, Miami, Fla.
View Bio

Harry Goldblatt Award Finalists

Winner
Inflammatory and Adhesion Related Genes are Up Regulated in Mononuclear Cells of Patients with Coronary Artery Disease
Christian Delles, M.D., FRCP(Glasg), FAHA, Mar a U. Moreno, Chiara Taurino, Ulf Neisius, William M. Miller, John D. McClure, Martin W. McBride, Anna F. Dominiczak, University of Glasgow, Glasgow, United Kingdom
Presentation Slides

ACE2 Over-Expression Regulates AT1, 026 AT2 and Mas Receptor Expression and Nitric Oxide Levels in Syn-ACE2Transgenic Mice
Eric Lazartigues, Ph.D., FAHA, Yumei Feng, Yanhui Cai, Lisa M. Harrison-Bernard, Louisiana State UniversityÂ Health Sciences Center, New Orleans, La.
Presentation Slides

Chronic Hypertension Enhances the 027 Presynaptic Effect of Baclofen in the Nucleus of the Solitary Tract
Weirong Zhang, Ph.D., Steve Mifflin, UT Health Science Center at San Antonio, San Antonio, Texas
Presentation Slides

Arthur C. Corcoran Memorial Lecture

Modification of Mineralocorticoid Receptor Function in Salt-sensitive Hypertension and Metabolic Syndrome
Toshiro Fujita, M.D. Professor and Chair, Department of Internal Medicine, University of Tokyo School of Medicine Tokyo, Japan
Presentation Slides

High Blood Pressure Research Council of Australia Young Investigator Award

Defining the Role(s) of Nox2-containing 028 NADPH Oxidase in the Cerebral Circulation
T. Michael De Silva, Department of Pharmacology, Monash University, Melbourne Australia, Grant R. Drummond, Brad R. Broughton Courtney Judkins, Christopher G. Sobey, Alyson A. Miller, Monash University, Clayton, Australia
Presentation Slides

Other Featured Presentations

Neuronal Nitric Oxide Synthase Beta: A Salt-Sensitive Splice Variant Expressed in the Macula Densa
Deyin Lu, Yilin Fu, Arnaldo Lopez-Ruiz, Rui Zhang, Ramiro Juncos, Davis R. Manning, Jr.,
Luis A Juncos, Ruisheng Liu; University of Mississippi Med Center, Jackson, Miss.
Presentation Slides

Spironolactone and Angiotensin-(1-7) in Salt-Induced Cardiac Injury
Jasmina Varagic, Sarfaraz Ahmad, KB Brosnihan, Carlos M Ferrario; Wake Forest University, Winston-Salem, N.C.
Presentation Slides

Enhanced Apelin/APJ System in the Paraventricular Nucleus of Rats After Myocardial Infarction
Qi Zhang, Ajeeth Pingili, Fanrong Yao, Stephen T O'Rourke, Chengwen Sun; North Dakota State University, Fargo, N.D.
Abstract

Proximal Tubule Cell-Specific Adenoviral Transfer of an Intracellular Angiotensin II Fusion Protein Elevates Blood Pressure by Activating AT1 Receptors in Rats
Xiao C. Li, Henry Ford Hospital, Detroit, Mich.; Julie L. Cook, Ochsner Clinic Foundation, New Orleans, La.; Isabelle Rubera, University of Nice-Sophia Antipolis, Parc Valrose, France; Fan Zhang, Henry Ford Hosp, Detroit, Mich.; Michel Tauc, University of Nice-Sophia Antipolis, Parc Valrose, France; Jia L. Zhuo, Henry Ford Hospital, Detroit, Mich.
View Poster

Highlighted Presentations — Friday

Lewis K. Dahl Memorial Lecture

Cardioprotective Effects of Cyclic GMP: Lessons from Animal Genetic Models
Christian Deschepper, M.D. Director of the Experimental Cardiovascular Biology Research Unit, Institut de recherch cliniques de Montreal, Montreal, Quebec
Presentation Slides

Featured Presentations

Hypertension in Response to Soluble FMS-Like Tyrosine Kinase-1 During Pregnancy: Role of Endothelin-1
Sydney Murphy, Babbette LaMarca, Kathy Cockrell, Joey P Granger; Univ of Mississippi Med Cntr, Jackson, Miss.
Abstract

MitoQ10 Reduces Mitochondrial Reactive Oxygen Species Production and AMP-Activated Protein Kinase Activity in Vessels from Patients with Type 2 Diabetes and Coronary Artery Disease
Ruth M Mackenzie, Carlene A Hamilton, William H Miller, Ian P Salt, Univ of Glasgow, Glasgow, United Kingdom; Michael P Murphy, MRC Mitochondrial Biology Unit, Cambridge, United Kingdom; Christian Delles, Anna F Dominiczak; Univ of Glasgow, Glasgow, United Kingdom
Presentation Slides

mPGES-1-Derived PGE2 Mediates Aldosterone Escape in Mice
Zhanjun Jia, Tianxin Yang; Univ of Utah, Salt Lake City, Utah
Presentation Slides

Central Neuropeptide Y (NPY) Deficiency Does Not Enhance the Dietary or Cardiovascular Responses to Chronic Activation of Melanocortin 3 and 4 Receptors (MC3/4R)
J. Nathan Freeman, Jussara M. do Carmo, John E. Hall, Alexandre A da Silva, Univ of Mississippi Medical Ctr, Jackson, Miss.
Poster Abstract

Extracellular Renal Cyclic GMP Modulates Pressure-Natriuresis Independently of Medullary Blood Flow and Renal Interstitial Hydrostatic Pressure
Brandon A. Kemp, Nancy L. Howell, David C. Lieb, Shetal H. Padia, Robert M. Carey, Univ of Virginia, Charlottesville, Va.
Poster Abstract

The Endothelial Mineralocorticoid Receptor Regulates Vasoconstrictor Tone and Blood Pressure
Aurelie Nguyen Dinh Cat Jr., Violaine Griol-Charhbili Jr., Smail MassaoudI Jr., INSERM Unit 872, Paris, France; Laurent Loufrani Sr., UMR CNRS-INSERM, 6214-771, Angers, France; Carlos Labat Sr., INSERM Unit 961, Vandoeuvre-les-Nancy, France; Patricia Neco Jr., INSERM Unit 637, Montpellier, France; Nathalie Panek-Huet, INSERM Unit 872, Paris, France; Laura Benjamin Sr., Beth Israel Deaconess Medical Ctr and Harvard Medical Sch, Boston, MA; Ana-Maria Gomez Sr., INSERM Unit 637, Montpellier, France; Nicolette Farman Sr., INSERM Unit 872, Paris, France; Patrick Lacolley Sr, INSERM Unit 961, Vandoeuvre-les-Nancy, France; Daniel Henrion Sr., UMR CNRS-INSERM, 6214-771, Angers, France; Frederic Jaisser Sr., INSERM Unit 872, Paris, France
Poster Abstract

Extracellular ATP Inhibits Transport-related Oxygen Consumption by the Thick Ascending Limb via Increasing NO
Guillermo B. Silva, Jeffrey L. Garvin, Henry Ford Hosp, Detroit, Mich.
Poster Abstract

Deficiency of Angiotensinogen in Adipocytes Decreases Systolic Blood Pressure in Older Male and Female C57bl/6 Mice
Frederique B. Yiannikouris, Lisa Cassis, Graduate Center for Nutritional Sciences, Lexington, Ky.
Poster Abstract

Highlighted Presentations — Saturday

Harriet Dustan Award Lecture

Pit Vipers, Fat Lips and Personalized Medicine
Nancy J. Brown, M.D., Vanderbilt University Medical Center, Nashville, Tenn.
Presentation Summary
Presentation Slides

Featured Presentations

Adipocyte Deficiency of Angiotensinogen Reduces the Development of Diet-Induced Obesity in Female Mice
Frederique B Yiannikouris, Manisha Gupte, Victoria English, Lisa Cassis; Graduate Cntr for Nutritional Sciences, Lexington, Ky.
Presentation Slides

Perivascular Adipose Tissue Contributes to Vascular Dysfunction in Hypertension Associated with Metabolic Syndrome
Chiara Marchesi, Talin Ebrahimian, Orlando Angulo, Pierre Paradis, Ernesto L Schiffrin; Lady Davis Institute, Montreal, Canada
Presentation Slides

High-sugar diet increases men’s blood pressure; gout drug protective

Vitamin D deficiency in younger women is associated with increased risk of high blood pressure in mid-life

The Top 10 Things You Are Missing if You Are Not Attending the 2009 High Blood Pressure Research Conference

Workshop — Systems Medicine Strategies in Hypertension: From Molecules to Patients
Keynote Presentation — Genes, Molecules, Systems Biology and Epidemiology — Bringing it All Together Through Framingham. Daniel Levy, M.D., Framingham, Mass.
State-of-the-art Presentations
The Donald Seldin Lecture — Progression of Kidney Disease and the Podocyte. Roger Wiggins, M.B., B.Chir., University of Michigan, Ann Arbor, Mich.
Lewis K. Dahl Memorial Lecture — Cardioprotective Effects of Cyclic GMP: Lessons from Animal Genetic Models. Christian Deschepper, M.D., Director of the Experimental Cardiovascular Biology Research Unit, Institut de recherché cliniques de Montreal, Montreal, Quebec
Arthur C. Corcoran Memorial Lecture — Modification of Mineralocorticoid Receptor Function in Salt-sensitive Hypertension and Metabolic Syndrome. Toshiro Fujita, M.D., Professor and Chair, Department of Internal Medicine, University of Tokyo School of Medicine Tokyo, Japan
Prestigious Awards
- Distinguished Scientist
- Louis B. Russell Jr. Memorial Award
- Harry Goldblatt New Investigator Awards
- Irvine Page – Alva Bradley Lifetime Achievement Award
- High Blood Pressure Research Council of Australia Young Investigator Award
- Harriet Dustan Award
Late-Breaking Abstracts
Networking opportunities with established investigators in HBPR research
Three Poster Sessions with over 350 Posters
- Poster Session 1
  - Aldosterone and Adrenal Mechanisms
  - Cardiac Hypertrophy and Dysfunction
  - Clinical Hypertension
  - Epidemiological Aspects of Hypertension
  - Genetics of Hypertension
  - Novel Therapeutic Approaches to Hypertension
  - Pathogenesis of Hypertension
  - Renal Hemodynamics and Vascular Function
- Poster Session 2
  - Angiotensin Receptors and Signal Transduction
  - Cardiovascular Renal Axis
  - Experimental Models and New Approaches
  - Gender and Hypertension
  - Inflammation, Immunity and Hypertension
  - Oxidative Stress
  - Peripheral Neural Mechanisms
  - Renal Inflammation, Injury and Diabetes
  - Vascular Biology
- Poster Session 3
  - Central Neural Mechanisms
  - Molecular and Cellular Physiology
  - Obesity, Insulin and Metabolic Factors
  - Pregnancy, Pediatrics and Hypertension
  - Regulation of the Renin Angiotensin System
  - Renal Tubular Transport and Natriuretic Factors
  - Vascular Remodeling and Dysfunction
  - Vascular Signaling
  - Vasoactive Mediators and Autacoids